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  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Immunology and Inflammation

    Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Christina Hertel et al.
    We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.
    1. Evolutionary Biology

    Evolution of empathetic moral evaluation

    Arunas L Radzvilavicius et al.
    Empathy can evolve and foster cooperation in a game-theoretic analysis of behavior.
    1. Evolutionary Biology

    Privatisation rescues function following loss of cooperation

    Sandra Breum Andersen et al.
    A population of pathogenic bacteria is found to respond to the loss of cooperation by privatising an essential function.
    1. Cell Biology
    2. Immunology and Inflammation

    Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

    Jessica F Walls et al.
    Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.
    1. Cell Biology
    2. Developmental Biology

    Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

    Ryuichi Fukuda et al.
    3D single cell imaging and genetic analyses reveal a new role of cardiac metabolism in cardiac wall morphogenesis.
    1. Cell Biology
    2. Developmental Biology

    In vivo genetic dissection of tumor growth and the Warburg effect

    Cheng-Wei Wang et al.
    A Drosophila tumor model reveals how the activation of an oncogenic pathway can lead to both tumor growth and a reprogramming of metabolism known as the Warberg effect.
    1. Genetics and Genomics

    Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution

    Matthias Meyer et al.
    DNA sequences from the Middle Pleistocene reveal that the extinct Eurasian straight-tusked elephants were closely related to today's African forest elephants (Loxodonta cyclotis) in Africa.
    1. Developmental Biology

    Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

    Xinde Zheng et al.
    The shutoff of aerobic glycolysis in neuronal differentiation is essential for neuronal survival.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Niels Bradshaw et al.
    Structures of active and inactive conformations of a PP2C family phosphatase reveal a conserved switch that controls enzymatic activity and point to an unexpected relationship between phosphatases and proteasomal proteases.