1,475 results found
    1. Cell Biology
    2. Neuroscience

    Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

    Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
    Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.
    1. Neuroscience

    Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier

    Fu Li, Gregory Artiushin, Amita Sehgal
    Metabolites, such as acylcarnitines, accumulate in Drosophila heads when endocytosis is blocked and reflects an increased need for sleep.
    1. Genetics and Genomics
    2. Neuroscience

    Orai-mediated calcium entry determines activity of central dopaminergic neurons by regulation of gene expression

    Rishav Mitra, Shlesha Richhariya, Gaiti Hasan
    Expression of the appropriate repertoire of membrane channels, essential for activity of flight-promoting central dopaminergic neurons of Drosophila, requires store-operated Ca2+ entry during late pupal development and early adults.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S Egan, Emily A O’Rourke ... Sunny Shin
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Computational and Systems Biology

    Statistical analysis supports pervasive RNA subcellular localization and alternative 3' UTR regulation

    Rob Bierman, Jui M Dave ... Julia Salzman
    Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.
    1. Cancer Biology

    A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

    Kailai Li, Junyi Liang ... Hui Meng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration

    Victoria L Czech, Lauren C O'Connor ... Alexandra B Byrne
    TIR-1 regulates both repair and destruction on either side of an injury axon.
    1. Developmental Biology

    Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

    Kayleigh Bozon, Hartmut Cuny ... Sally L Dunwoodie
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Ecology

    Plant-associated CO2 mediates long-distance host location and foraging behaviour of a root herbivore

    Carla CM Arce, Vanitha Theepan ... Ricardo AR Machado
    The larvae of the western corn rootworm use root-emitted CO2 to successfully locate the most suitable host plant.

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