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    1. Cancer Biology
    2. Cell Biology

    A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

    Alex Weiss, Cassandra D'Amata ... Madeline N Hayes
    Modeling glioblastoma using expression of relevant human oncogenes in syngeneic zebrafish offers a powerful platform for current and future biological discovery, diagnostics, and therapeutic testing in an intact tumor microenvironment.
    1. Developmental Biology

    The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

    Rei Yagasaki, Ryo Nakamura ... Yoshiko Takahashi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt
    Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
    1. Cell Biology

    Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells

    Amélie-Rose Boudjema, Rémi Balagué ... Alice Meunier
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Plant Biology

    A shade-responsive microProtein in the Arabidopsis ATHB2 gene regulates elongation growth and root development

    Ashleigh Edwards, Maurizio Junior Chiurazzi ... Stephan Wenkel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

    Edgar M Pera, Josefine Nilsson-De Moura ... Ivana Milas
    An extracellular proteolytic pathway involving the serine protease HtrA1, its inhibitor SerpinE2, and the transmembrane proteoglycan Syndecan-4 control collective migration of neural crest cells in the developing embryo.
    1. Genetics and Genomics
    2. Neuroscience

    Sibling chimerism among microglia in marmosets

    Ricardo C.H. del Rosario, Fenna M. Krienen ... Steven A. McCarroll
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster

    Julia R Port, Dylan H Morris ... Vincent J Munster
    An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.
    1. Neuroscience

    FSHβ links photoperiodic signaling to seasonal reproduction in Japanese quail

    Gaurav Majumdar, Timothy A Liddle ... Tyler Stevenson
    Molecular analyses reveal the neuroendocrine control of seasonal life-history transitions in birds.
    1. Evolutionary Biology

    Major patterns in the introgression history of Heliconius butterflies

    Yuttapong Thawornwattana, Fernando Seixas ... James Mallet
    The full-likelihood multispecies coalescent approach is useful for studying species groups with high rates of introgression from whole-genome sequence data.
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