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    1. Epidemiology and Global Health
    2. Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu, Katrina J Sullivan ... Lauralyn McIntyre
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Plant Biology

    BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance

    Bo Zhang, Mattias Holmlund ... Ove Nilsson
    The abundance of the PIF4 transcription factor, central in light and temperature signaling, is controlled by an E3 ligase encoded by BOP proteins.
    1. Cancer Biology

    Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity

    Ophir Shani, Yael Raz ... Neta Erez
    Metastases-associated fibroblasts show stage-dependent transcriptional plasticity and their rewiring is regulated by Myc.
    1. Cell Biology

    A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

    Robinson Arce-Molina, Francisca Cortés-Molina ... Alejandro San Martín
    A user-friendly genetically-encoded fluorescent sensor of improved dynamic range is introduced to facilitate the study of mitochondrial metabolism and diversity.
    1. Cell Biology

    An aging-independent replicative lifespan in a symmetrically dividing eukaryote

    Eric C Spivey, Stephen K Jones Jr ... Ilya J Finkelstein
    A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryonic origin and serial homology of gill arches and paired fins in the skate, Leucoraja erinacea

    Victoria A Sleight, J Andrew Gillis
    Development from dual-origin mesenchyme with common competence explains anatomical parallels and shared patterning of the jawed vertebrate gill arch and paired fin skeletons.
    1. Evolutionary Biology

    Microstructural and crystallographic evolution of palaeognath (Aves) eggshells

    Seung Choi, Mark E Hauber ... David J Varricchio
    The eggshells of palaeognath birds (e.g. ostrich, moa, kiwi, emu) have diverse homology and convergent features, and are useful modern analogues for the evolution of non-avian dinosaur eggshells.
    1. Developmental Biology
    2. Evolutionary Biology

    Resegmentation is an ancestral feature of the gnathostome vertebral skeleton

    Katharine E Criswell, J Andrew Gillis
    Shared complexities of backbone segmentation between cartilaginous fishes and tetrapods originate much earlier in vertebrate evolution than previously thought.
    1. Ecology
    2. Neuroscience
    Silhouette of a zebra finch on a blue background.

    The Natural History of Model Organisms: Neurogenomic insights into the behavioral and vocal development of the zebra finch

    Mark E Hauber, Matthew IM Louder, Simon C Griffith
    The genetic and behavioral diversity of the zebra finch, both in the wild and in captivity, make it well-suited for neuroethological studies of vocal learning, culture, and social bonding.