3,695 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng et al.
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
  1. Science Policy: Reforming research assessment

    Randy Schekman, Mark Patterson
    It is time for the research community to rethink how the outputs of scientific research are evaluated and, as the San Francisco Declaration on Research Assessment makes clear, this should involve replacing the journal impact factor with a broad range of more meaningful approaches.
    Editorial
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  2. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
  3. Point of View: Overflow in science and its implications for trust

    Sabina Siebert et al.
    Interviews with senior biomedical researchers reveal a perceived decline in trust in the scientific enterprise, in large part because the quantity of new data exceeds the field's ability to process it appropriately.
  4. Research: Publication bias and the canonization of false facts

    Silas Boye Nissen et al.
    Publication bias, in which positive results are preferentially reported by authors and published by journals, can restrict the visibility of evidence against false claims and allow such claims to be canonized inappropriately as facts.
    1. Computational and Systems Biology

    Meta-Research: Releasing a preprint is associated with more attention and citations for the peer-reviewed article

    Darwin Y Fu, Jacob J Hughey
    An analysis of more than 70,000 journal articles, including 5405 that were first released as a preprint on bioRxiv, shows that articles with a preprint received 49% more attention and 36% more citations than articles without one.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
  5. Research: Theory, models and biology

    Wenying Shou et al.
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
    Editorial
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  6. Point of View: Priority of discovery in the life sciences

    Ronald D Vale, Anthony A Hyman
    Disclosing work prior to submission to a journal would benefit scientists seeking to be acknowledged for their discoveries.

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