7,981 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Place-cell capacity and volatility with grid-like inputs

    Man Yi Yim, Lorenzo A Sadun ... Thibaud Taillefumier
    A very large number of place-field maps can be robustly learned by association of external cues with the grid-driven response, however plasticity in the grid-cell inputs renders the place-cell responses volatile.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

    Zhanying Feng, Zhana Duren ... Yong Wang
    Integrating chromatin accessibility and gene expression data into context-specific regulatory networks can provide better regulatory categories for heritability enrichment and relevant tissue identification.
    1. Neuroscience

    Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments

    Jordan Breffle, Hannah Germaine ... Paul Miller
    Computational simulations and data analysis show that random clustering in the connections of neurons receiving minimal external cues can generate place fields and their spontaneous activation in trajectory-like sequences.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui, Yanbin V Wang ... Daniel A Butts
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.
    1. Neuroscience

    Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity

    Tianyu Tang, Timothy A Blenkinsop, Eric J Lang
    The importance of synchronous Purkinje cell complex spikes for controlling cerebellar output was investigated by simultaneously recording from cerebellar nuclear cells and arrays of Purkinje cells that synapse onto them.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Estimating the potential to prevent locally acquired HIV infections in a UNAIDS Fast-Track City, Amsterdam

    Alexandra Blenkinsop, Mélodie Monod ... Oliver Ratmann
    Phylogenetic evidence suggests that the majority of HIV infections occurring in the UNAIDS Fast-track city Amsterdam continue to have an Amsterdam resident as source, indicating that the majority of HIV infections in Amsterdam could be prevented through city-level interventions.
    1. Immunology and Inflammation

    Kidins220 regulates the development of B cells bearing the λ light chain

    Anna-Maria Schaffer, Gina Jasmin Fiala ... Susana Minguet
    The scaffold protein Kidins220 regulates the development of λLC B cells by supporting B cell precursor survival and optimizing pre‑BCR and BCR signaling.
    1. Cancer Biology
    2. Developmental Biology

    Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila

    Karine Narbonne-Reveau, Elodie Lanet ... Cédric Maurange
    Sequentially expressed temporal transcription factors in neural stem cells during early development determine which progeny can undergo malignant transformation upon dedifferentiation.
    1. Ecology
    2. Microbiology and Infectious Disease

    Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures

    Mauricio Seguel, Felipe Montalva ... Nicole Gottdenker
    In years with colder ocean temperatures, fur seal pups receive more maternal care and have a better energy balance, clearing hookworm infection earlier, which increases their chances of survival.
    1. Computational and Systems Biology
    2. Neuroscience

    Daily electrical activity in the master circadian clock of a diurnal mammal

    Beatriz Bano-Otalora, Matthew J Moye ... Mino DC Belle
    Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.

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