Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.

A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection.

A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.

Advances in quantitative phase and polarized light microscopy, combined with deep learning, reveal the architecture of human brain tissue.

Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.

Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.

A novel panel of homoFRET biosensors that detect kinase and second messenger activity, called FLAREs, enables multiparameter imaging of signaling activities within a single live cell with a quantitative and ratiometric readout.

The combination of theoretical modeling and quantitative live imaging revealed that the repressor proteins work cooperatively or anti-cooperatively depending on enhancer architecture.

A new method for quantitative assessment of altered regulatory potential of human enhancers bearing disease-associated mutations using live imaging in zebrafish embryos.

Quantitative super resolution imaging, in live mammalian cells, reveals a direct relationship between protein clustering dynamics and the number of mRNA transcribed at an endogenous gene locus.