44 results found
    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    COVID-19: A Collection of Articles

    Edited by Diane M Harper et al.
    eLife has published the following articles on SARS-CoV-2 and COVID-19.
    1. Cell Biology
    2. Developmental Biology

    Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

    Wing Tak Wong et al.
    Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.
  1. Annual Report: 2020 in review

    We reflect on eLife’s efforts to drive change in scientific and medical publishing during an eventful year.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang et al.
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.
    1. Cancer Biology
    2. Computational and Systems Biology

    A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

    Adam C Palmer et al.
    Drugs in a curative chemotherapy regimen are independently effective and resisted by different mechanisms, so cancer cells have little chance of surviving all drugs, and this benefit occurs without synergistic interactions.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

    Hyung Suk Oh et al.
    CRISPR genome editing technology can efficiently introduce mutations into lytic and latent HSV genomes to block lytic replication and reactivation of latent herpes simplex virus genome though differential mechanisms.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis et al.
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth et al.
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
    1. Microbiology and Infectious Disease

    Revisiting the guidelines for ending isolation for COVID-19 patients

    Yong Dam Jeong et al.
    Compared with the approach isolating COVID-19 patients for a fixed period, the approach using repeated PCR testing mitigates unnecessarily lengthy isolation of patients while minimizing the risk of further transmission.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston et al.
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.

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