347 results found
    1. Neuroscience

    GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine

    Takashi Yamamoto, Kayoko Ueji ... Shinya Ugawa
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Flexibility in PAM recognition expands DNA targeting in xCas9

    Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
    xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete
    1. Cell Biology

    AXONAL distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

    Kanako Shinno, Yuri Miura ... Kanae Ando
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response

    Jiayi Fan, Nalini Dhingra ... Xiaolan Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
    Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
    1. Microbiology and Infectious Disease

    Reactive Oxygen Detoxification Contributes to Mycobacterium abscessus Antibiotic Survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

    Binayak Sarkar, Jyotsna Singh ... Rajesh S Gokhale
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    Leonid Peshkin, Enrico Maria Daldello ... Catherine Jessus
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates

    Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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