Unveiling Na_V1.6's role in sensitizing Slack to quinidine disruption redefines KCNT1-related epilepsy treatment strategies.

2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.

A folding-function model for the guanidine-IV riboswitch under both guanidine-free and guanidine-present conditions offers valuable insights into its regulatory mechanism.

RNA aptamers that are closely related and share a common scaffold can readily adapt to recognize new ligands through changes in just a few nucleotides.

A naturally-occurring small molecule acts as a chemical chaperone in vivo to alter the folding of a budding yeast septin and promote an oligomerization pathway that was lost during evolution.

The finding that fly maggots, equipped with only 10,000 neurons, process reinforcement not only by value but also by specific quality reveals a basic operating principle of brains and challenges current models of memory organization.

A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.

A fast and accurate decision-making strategy observed in bees, and reproduced in a neurally-grounded model, suggests a robust, risk-averse decision strategy suitable for when sampling and errors are both costly.

Inter-individual variabilities in nicotine aversion are linked with responses of the interpeduncular nucleus to the drug.

The taste system of fruit flies is activated by broad classes of fatty acids and can discriminate between different classes, revealing previously underappreciated complexity in the coding of tastants.