A novel mathematical method for screening new drugs for pro-arrhythmic cardiotoxicity without using animals or costly drug-specific computer simulations is proposed.
Mouloud Bouhadfane, Attila Kaszás ... Frédéric Brocard
The pain mediator bradykinin was found to sensitize spinal motoneurons by a direct postsynaptic action, questioning the role of motoneurons in the assessment of hyperalgesia since the withdrawal motor reflex is commonly used as a surrogate pain model.
Neurons in the lateral habenula are activated by pain, bitterness and social defeat, and their responses are dynamically shaped by learning, suggesting a role in experience-dependent selection of behavioral actions to stressors.
Edoardo Bistaffa, Alba Marín-Moreno ... Fabio Moda
The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.
Conventional studies have focused on enzymatic residues directly involved in catalysis; dissecting a potential interaction network within which these ‘catalytic residues’ are embedded provides insights fundamental to enzyme function, evolution, and engineering.
Madeline E Sherlock, Narasimhan Sudarsan ... Ronald R Breaker
A riboswitch class has been discovered for phosphoribosyl pyrophosphate, the biochemical precursor of nucleotides, and this novel RNA sensor commonly operates in tandem with a guanine aptamer to function like a Boolean logic gate.
Live imaging and taste behavior analyses show that related members of the Gr28 gene subfamily are expressed in largely non-overlapping sets of neurons and mediate opposing taste behaviors.
Jelke Jan Fros, Isabelle Dietrich ... Peter Simmonds
RNA virus replication is attenuated by an intrinsic restriction mechanism after introducing CpG/UpA dinucleotides into both non-translated and coding regions of viral genomes, which may be exploited in the design of attenuated virus vaccines.
