115 results found
    1. Physics of Living Systems

    A microfluidic device for inferring metabolic landscapes in yeast monolayer colonies

    Zoran S Marinkovic et al.
    Metabolic gradients underlie gene expression patterns within spatially controlled expanding 2D microbial colonies.
    1. Microbiology and Infectious Disease

    Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations

    Catherine R Armbruster et al.
    Subpopulations of polysaccharide producer and surface explorer cells play specialized roles in early Pseudomonas aeruginosa biofilm formation.
    1. Microbiology and Infectious Disease

    Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA

    Tera C Levin et al.
    Legionella pneumophila can be inhibited by its own antimicrobial, HGA (homogentisic acid), but its density-dependent resistance to HGA restricts the potential for self-harm.
    1. Microbiology and Infectious Disease

    Bacteria: How Legionella defend their turf

    Elisa D Hughes, Michele S Swanson
    Communities of bacteria that cause Legionnaire’s disease repel other bacteria by secreting an acid called HGA.
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    1. Ecology
    2. Evolutionary Biology

    Nitric oxide radicals are emitted by wasp eggs to kill mold fungi

    Erhard Strohm et al.
    To protect their food and themselves against detrimental mould fungi, the eggs of a wasp species synthesize and emit remarkable amounts of gaseous nitrogen oxides that are highly effective antimicrobials.
    1. Computational and Systems Biology
    2. Neuroscience

    NetPyNE, a tool for data-driven multiscale modeling of brain circuits

    Salvador Dura-Bernal et al.
    The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.
    1. Neuroscience

    Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

    Jie Zhang et al.
    An effective and reversible mouse glaucoma model that replicates the secondary glaucoma in human patients caused by silicone oil after retina surgeries presents significant neurodegeneration, and is suitable for neuroprotectants selection.
    1. Physics of Living Systems

    A multiphase theory for spreading microbial swarms and films

    Siddarth Srinivasan et al.
    A multiphase hydrodynamic theory reveals that the dynamics of colony expansion in microbial swarms and biofilms are limited by the constraints of water and nutrient availability.
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer et al.
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

    Zachary F Hallberg et al.
    A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.

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