192 results found
    1. Biochemistry and Chemical Biology

    Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

    Syed M Moin, Sinisa Urban
    Intramembrane proteases identify target proteins in a different way from other proteases.
    1. Microbiology and Infectious Disease

    Strong inter-population cooperation leads to partner intermixing in microbial communities

    Babak Momeni, Kristen A Brileya ... Wenying Shou
    Simulations and experiments on systems containing two different populations of microorganisms show that interactions that benefit at least one of the populations can lead to communities with stable compositions, and that strong cooperation between two populations can lead to communities in which both populations are mixed together.
    1. Ecology
    2. Physics of Living Systems

    Spatial dilemmas of diffusible public goods

    Benjamin Allen, Jeff Gore, Martin A Nowak
    A simple model reveals the roles of colony geometry and diffusion rate in allowing microbes to cooperate by sharing public goods.
    1. Immunology and Inflammation

    T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

    Karen E Tkach, Debashis Barik ... Grégoire Altan-Bonnet
    Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

    Christopher Batram, Nicola G Jones ... Markus Engstler
    The VSG gene controls its monoallelic expression, and expression site activity determines developmental progression.
    1. Microbiology and Infectious Disease

    Cell cycle constraints on capsulation and bacteriophage susceptibility

    Silvia Ardissone, Coralie Fumeaux ... Patrick H Viollier
    A multi-layered and conserved cell cycle mechanism prevents capsulation, long known as a bacterial virulence determinant, in G1-phase and concurrently licenses bacteriophage-mediated genetic exchange prior to entry into S-phase.
    1. Epidemiology and Global Health

    Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission

    Michael T White, Stephan Karl ... Azra C Ghani
    Mathematical models of the build-up and depletion of the hypnozoite reservoir in the liver can inform the design of treatment strategies for preventing Plasmodium vivax relapse infections.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolving a 24-hr oscillator in budding yeast

    Gregg A Wildenberg, Andrew W Murray
    New complex traits can evolve through the elimination of genes in multiple unrelated pathways, rather than through the creation of new gene functions.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Native architecture of the Chlamydomonas chloroplast revealed by in situ cryo-electron tomography

    Benjamin D Engel, Miroslava Schaffer ... Wolfgang Baumeister
    The first 3D views of the native algal chloroplast provide new insights into thylakoid biogenesis, photosynthesis, and carbon fixation.
    1. Microbiology and Infectious Disease

    Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa

    Michele LeRoux, Robin L Kirkpatrick ... Joseph D Mougous
    The death of bacterial kin cells releases a danger signal that activates a posttranscriptional response in surviving cells, resulting in the rapid elaboration of interbacterial competition factors.

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