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    1. Computational and Systems Biology
    2. Physics of Living Systems

    Light-driven synchronization of optogenetic clocks

    Maria Cristina Cannarsa, Filippo Liguori ... Roberto Di Leonardo
    Introducing the optorepressilator, a synthetic genetic oscillator that can be synchronized, entrained, and detuned by green light to precisely control periodic gene expression in single cells or entire bacterial populations.
    1. Microbiology and Infectious Disease

    Cyclic di-GMP as an antitoxin regulates bacterial genome stability and antibiotic persistence in biofilms

    Hebin Liao, Xiaodan Yan ... Yingying Pu
    c-di-GMP and HipH function as a toxin-antitoxin-like module to regulate persister cell formation in bacterial biofilms.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Merging multi-omics with proteome integral solubility alteration unveils antibiotic mode of action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho
    Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.
    1. Cell Biology

    Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

    Iuliia Ferling, Steffen Pfalzgraf ... Spencer A Freeman
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

    Arijit Chakraborty, Arunava Bandyopadhaya ... Laurence G Rahme
    The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A General Mechanism for the General Stress Response in Bacteria

    Rishika Baral, Kristin Ho ... Niels Bradshaw
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Should I stay or should I go? Spatio-temporal dynamics of bacterial biofilms in confined flows

    Massinissa Benbelkacem, Gabriel Ramos ... Yohan Davit
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Hosts manipulate lifestyle switch and pathogenicity heterogeneity of opportunistic pathogens in the single-cell resolution

    Ziguang Wang, Shuai Li ... Wei Liu
    The host acts as an important factor to control the phenotypic heterogeneity of individual symbionts.
    1. Microbiology and Infectious Disease

    Bacteria are a major determinant of Orsay virus transmission and infection in Caenorhabditis elegans

    Brian G Vassallo, Noemie Scheidel ... Dennis H Kim
    Distinct members of the Caenorhabditis elegans microbiota can have widely divergent effects on Orsay virus transmission, such that associated bacteria can effectively determine host susceptibility versus resistance to viral infection.