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    1. Cell Biology
    2. Neuroscience

    Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells

    A Catalina Vélez-Ortega, Mary J Freeman ... Gregory I Frolenkov
    The remarkable lifelong stability of mechanotransducing stereocilia of the inner ear hair cells depends on the activity of the transduction ion channels located at the tips of these mechanosensory projections.
    1. Cell Biology

    Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    Yajun Zhai, Peiyi Liu ... Gongzheng Hu
    The combination therapy of colistin, artesunate, and EDTA could serve as a promising approach to combat colistin-resistant Salmonella infections by disrupting bacterial membranes, collapsing proton motive force, and increasing reactive oxygen species levels.
    1. Cell Biology

    Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes

    Michelle E Maxson, Xenia Naj ... Sergio Grinstein
    The diffusional barrier formed between phagocyte integrin and fungal glucans preserves the microbiostatic phagocytic environment generated during the frustrated phagocytosis of Candida albicans hypha.
    1. Plant Biology

    Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry

    Firas Bou Daher, Yuanjie Chen ... Siobhan A Braybrook
    Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
    1. Neuroscience

    Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

    Yu-Feng Xie, Jane Yang ... Steven A Prescott
    Because nociceptors can achieve similar excitability using different sodium channel subtypes, it is difficult to know which channels are being used yet this information is critical for predicting if subtype-selective drugs will reduce pain.
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S. Thum
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    NF-κB oscillations translate into functionally related patterns of gene expression

    Samuel Zambrano, Ilario De Toma ... Alessandra Agresti
    NF-κB oscillations synchronize to external perturbations as a damped oscillator, producing different transcription dynamics.
    1. Cancer Biology

    Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

    Mee Rie Sheen, Jennifer L Fields ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Developmental Biology

    The embryonic role of juvenile hormone in the firebrat, Thermobia domestica, reveals its function before its involvement in metamorphosis

    James W Truman, Lynn M Riddiford ... Michelle Herko
    This sesquiterpene hormone likely acted as a morphogenesis-to-differentiation switch in archaic embryos before it evolved its postembryonic function as the status quo regulator of insect metamorphosis.