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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria

    M Sabrina Pankey, Randi L Foxall ... Cheryl A Whistler
    Selective forces imposed by the squid animal host drive rapid adaptation of non-native Vibrio fischeri bacteria through convergent mutations of large effect, unmasking preexisting coordinated regulation of symbiosis.
    1. Microbiology and Infectious Disease

    Two enhancer binding proteins activate σ54-dependent transcription of a quorum regulatory RNA in a bacterial symbiont

    Ericka D Surrett, Kirsten R Guckes ... Tim I Miyashiro
    Genetic analysis and host colonization assays reveal a regulatory mechanism that enables a bacterial symbiont to bypass the constraints of quorum sensing to activate specific cellular traits necessary to colonize its host.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Microbiology and Infectious Disease

    Severe infections emerge from commensal bacteria by adaptive evolution

    Bernadette C Young, Chieh-Hsi Wu ... Daniel J Wilson
    Life-threatening S. aureus infections emerge from commensal nose bacteria in association with repeatable adaptive evolution.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantifying changes in the T cell receptor repertoire during thymic development

    Francesco Camaglia, Arie Ryvkin ... Nir Friedman
    Sequence signatures can be used to discriminate between selected and non-selected immune repertoires at different stages only at the collective population level but not at the level of single cells.
    1. Microbiology and Infectious Disease

    Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa

    Dominique H Limoli, Elizabeth A Warren ... George A O'Toole
    Pseudomonas aeruginosa coordinates invasion and destruction of Staphylococcus aureus communities by modulating single-cell and collective motility.
    1. Microbiology and Infectious Disease

    Density-dependent resistance protects Legionella pneumophila from its own antimicrobial metabolite, HGA

    Tera C Levin, Brian P Goldspiel, Harmit S Malik
    Legionella pneumophila can be inhibited by its own antimicrobial, HGA (homogentisic acid), but its density-dependent resistance to HGA restricts the potential for self-harm.
    1. Microbiology and Infectious Disease

    Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

    Andrew A Bridges, Bonnie L Bassler
    The global pathogen Vibrio cholerae monitors environmental polyamines to garner information about numbers of ‘self’ versus ‘other’ in the vicinity, and in response, to remain or disperse from biofilms.
    1. Microbiology and Infectious Disease

    Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes

    William J Watterson, Melikhan Tanyeri ... Savaş Tay
    High-throughput droplet-based cultivation of gut microbes reduces biases of traditional cultivation strategies and thereby enables detection of difficult-to-culture organisms, which is required in applications such as antibiotic screening.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Bacteria: To biofilm or not to biofilm

    Shravan Pradeep, Paulo E Arratia
    A new model helps to predict under which conditions a species of bacteria will switch to a static lifestyle.
    Version of Record
    Insight