Upon genotoxic stress, the FBXL10-RNF68-RNF2 ubiquitin ligase complex mono-ubiquitylates histone H2A and mediates H2A/H2A.Z exchange to repress transcription and ensures proper high fidelity homologous recombination repair.

RNA molecules cause the proteins involved in the formation of germ granules to coalesce into liquid droplets.

Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.

Interactions between viral RNA and the integrase enzyme are required for HIV-1 particles to become infectious, a process that can be disrupted through multiple mechanisms.

An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.

The discovery of a biomolecular condensate involved in DNA replication has wide ranging implications.

Some RNAs in mammalian cells can help to silence the DNA they are transcribed from.

HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.

Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.

In an in vitro RNA replication system, an RNA spontaneously diversifies and continuously evolves through coevolution with parasitic entities.