A luminescence-based imaging system is presented that allows soil-based environmental stimuli to be studied in root systems under physiologically relevant conditions.

Transcriptomic comparison of inflammatory and steady-state osteoclasts reveals differences in their ability to sense their environment, which makes it possible to selectively inhibit inflammatory osteoclastogenesis and reduce bone loss in osteoporosis.

With three simple steps in 48 hr, EZ Clear effectively renders adult mouse organs optically transparent while simultaneously preserving signal from synthetic and endogenous fluorescent reporters and is compatible with wholemount immunostaining and cryosectioning followed by histological or immunofluorescent staining.

A discrete group of interconnected neurons are shown to drive aggressive social interactions in Drosophila females and genetic tools to manipulate these neuronal cell types are provided.

The plexin family of semaphorin receptors regulate Hedgehog pathway activity via a conserved GAP domain and FYN kinase phosphorylation site in their cytoplasmic domain.

Loss of a developmentally essential gene in adulthood is tolerated in mice, thus offering potential therapeutic options for Alzheimer's and Parkinson's disease.

Structural and functional analysis reveals the mechanistic basis for mammalian target of rapamycin (mTOR)-dependent roles of DEP domain-containing mTOR interacting protein (DEPTOR) in cancer and metabolic regulation.

Chemogenetic silencing reveals that entorhinal neurons require ongoing activity for survival, suggesting that their normal physiology may render them vulnerable to pathologies that impair transmission.

Analyses of allelic- and socially-biased gene expression reveal that suppressed recombination causes most of the expression differences in the social supergene, with only few differences due to socially antagonistic selection.

Inducible transcription in the brain encodes detailed aspects of recent experience.