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    1. Cell Biology
    2. Computational and Systems Biology

    Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

    Andrew D Bailey, Jason Talkish ... Manuel Ares
    A method enabling identification of more than 100 RNA modifications in single ribosomal RNA molecules uncovers new classes of modified ribosomes.
    1. Genetics and Genomics
    2. Plant Biology

    Genetic basis of sRNA quantitative variation analyzed using an experimental population derived from an elite rice hybrid

    Jia Wang, Wen Yao ... Qifa Zhang
    The expression of small RNAs (or sRNAs) is regulated not only by mRNA expression, but also by their own regulatory elements and by sRNA biogenesis genes.
    1. Cell Biology
    2. Genetics and Genomics

    Endogenous RNA interference is driven by copy number

    Cristina Cruz, Jonathan Houseley
    The ability to target transcripts from high-copy regions of the genome is an emergent property of a minimal RNA interference system.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

    Raeann Goering, Laura I Hudish ... J Matthew Taliaferro
    The molecular determinants for neuronal subcellular RNA transport by FMRP are defined, with interactions between RNA G-quadruplexes and the RGG domain of FMRP being of critical importance.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Engineering ER-stress dependent non-conventional mRNA splicing

    Weihan Li, Voytek Okreglak ... Peter Walter
    Ire1's RNase specificity and its cleavage sites coordination shape the evolutionary specialization of the unfolded protein response.
    1. Chromosomes and Gene Expression

    Translation affects mRNA stability in a codon-dependent manner in human cells

    Qiushuang Wu, Santiago Gerardo Medina ... Ariel Alejandro Bazzini
    Genomic-profiles and reporters reveal that the three-nucleotide ‘words’ read by the ribosome, codons, have a strong effect on mRNA stability, impacting the homeostatic mRNA and protein levels in human cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

    Zhiyun Ge, Bao Lin Quek ... J Robert Hogg
    The RNA-binding protein PTBP1 is recruited to sites near stop codons in retroviral and human mRNAs, shielding them from detection and degradation by the nonsense-mediated mRNA decay pathway.
    1. Genetics and Genomics
    2. Neuroscience

    The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

    Shahar Alon, Sandra C Garrett ... Eli Eisenberg
    The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repression of interrupted and intact rDNA by the SUMO pathway in Drosophila melanogaster

    Yicheng Luo, Elena Fefelova ... Alexei A Aravin
    SUMO-dependent pathway is responsible for selective repression of damaged rDNA and silencing of intact surplus units revealing an epigenetic mechanism that controls the differential expression of identical sequences in the same cell.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

    Sarah Gilbertson, Joel D Federspiel ... Britt Glaunsinger
    Messenger RNA degradation alters protein trafficking to control transcription.