3,695 results found
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc et al.
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Neuroscience

    Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

    Justin K O'Hare et al.
    Fast-spiking interneurons of the dorsolateral striatum are found to provide a microcircuit mechanism driving the circuit properties and behavioral adaptations that characterize habit.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

    Adam S Dingens et al.
    HIV vaccine-induced binding and neutralizing antibody epitope specificities were mapped at high resolution directly from polyclonal sera, overcoming shortcomings in traditional serum mapping approaches and enabling highly detailed vaccine design.
    1. Ecology
    2. Microbiology and Infectious Disease

    The diversity and function of sourdough starter microbiomes

    Elizabeth A Landis et al.
    In the most comprehensive survey of sourdough starter biodiversity, this work identifies processes that control the diversity and function of sourdough microbiomes at a continental scale.
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.
    1. Neuroscience

    Thalamocortical Synapses: Like a clock in the rabbit's visual cortex

    Frédéric Chavane, Diego Contreras
    Three rules govern the connectivity between neurons in the thalamus and inhibitory neurons in the visual cortex of rabbits.
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    1. Developmental Biology

    ZP4 confers structural properties to the zona pellucida essential for embryo development

    Ismael Lamas-Toranzo et al.
    Zona pellucida requires ZP4 protein to efficiently protect the developing embryo during in vivo pre-implantation development.
    1. Developmental Biology

    Reproduction: What is a placental mammal anyway?

    Patrick Abbot, John A Capra
    Many developmental functions in marsupials and eutherian mammals are accomplished by different tissues, but similar genes.
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    1. Neuroscience

    Cerebellar implementation of movement sequences through feedback

    Andrei Khilkevich et al.
    The cerebellum can learn a sequence of responses by using a feedback signal from the previous movement to learn the next one.
    1. Biochemistry and Chemical Biology

    Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics

    Kevin C Hadley et al.
    STOMP is a technique that can determine the proteomic composition of any feature that is identifiable by laser scanning microscopy and is at least one cubic micron in size.

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