3,074 results found
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc et al.
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Developmental Biology

    Reproduction: What is a placental mammal anyway?

    Patrick Abbot, John A Capra
    Many developmental functions in marsupials and eutherian mammals are accomplished by different tissues, but similar genes.
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    1. Neuroscience

    Learning: How the cerebellum learns to build a sequence

    Reza Shadmehr
    Rabbits can learn the biological analogue of a simple recursive function by relying only on the neurons of the cerebellum.
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    1. Neuroscience

    Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

    Justin K O'Hare et al.
    Fast-spiking interneurons of the dorsolateral striatum are found to provide a microcircuit mechanism driving the circuit properties and behavioral adaptations that characterize habit.
    1. Epidemiology and Global Health

    National and regional seasonal dynamics of all-cause and cause-specific mortality in the USA from 1980 to 2016

    Robbie M Parks et al.
    All parts of the USA are similarly adapted to temperature seasonality, although mortality seasonality, and how it has changed since the 1980s, depend on age and sex.
    1. Human Biology and Medicine
    2. Neuroscience

    Characterizing a psychiatric symptom dimension related to deficits in goal-directed control

    Claire M Gillan et al.
    A dimensional approach to psychiatry demonstrates the specificity and generalizability of a neurocognitive marker of compulsive behavior and intrusive thought via large-scale online testing.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Developmental Biology

    ZP4 confers structural properties to the zona pellucida essential for embryo development

    Ismael Lamas-Toranzo et al.
    Zona pellucida requires ZP4 protein to efficiently protect the developing embryo during in vivo pre-implantation development.
    1. Neuroscience

    Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

    Youna Vandaele et al.
    Dorsomedial and dorsolateral striatal neural activity differ during early learning of action sequences but do not change with performance improvement across sessions, and become similar after extended training.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites

    Peter Major et al.
    Transporters shared by fungal intracellular parasites provide new insights into the evolution of nucleotide and energy parasitism.

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