5,944 results found
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery, Abimael Cruz-Migoni ... Terence H Rabbitts
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Tempo and mode of gene expression evolution in the brain across primates

    Katherine Rickelton, Trisha M Zintel ... Courtney C Babbitt
    Larger phylogenetic context is required to understand human and nonhuman primate brain evolution.
    1. Developmental Biology
    2. Genetics and Genomics

    DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility

    Emilie Dujardin, Marjolaine André ... Maëlle Pannetier
    The absence of DMRT1 induces a male-to-female sex reversal in XY rabbits and complete infertility in both sexes.
    1. Biochemistry and Chemical Biology

    Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics

    Kevin C Hadley, Rishi Rakhit ... Avijit Chakrabartty
    STOMP is a technique that can determine the proteomic composition of any feature that is identifiable by laser scanning microscopy and is at least one cubic micron in size.
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc, Isaac B Daudelin ... Véronique Dartois
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

    Adam S Dingens, Payal Pratap ... Jesse D Bloom
    HIV vaccine-induced binding and neutralizing antibody epitope specificities were mapped at high resolution directly from polyclonal sera, overcoming shortcomings in traditional serum mapping approaches and enabling highly detailed vaccine design.
    1. Developmental Biology

    ZP4 confers structural properties to the zona pellucida essential for embryo development

    Ismael Lamas-Toranzo, Noelia Fonseca Balvís ... Pablo Bermejo-Álvarez
    Zona pellucida requires ZP4 protein to efficiently protect the developing embryo during in vivo pre-implantation development.
    1. Cell Biology

    Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

    Brett C Baggett, Kevin R Murphy ... Gideon Koren
    Ex vivo, in vitro, and computational modeling studies indicate a persistence of myofibroblast senescence in the infarct border zone with age which can disrupt conduction and promote arrhythmias via senescent myofibroblast-cardiomyocyte coupling.
    1. Ecology
    2. Microbiology and Infectious Disease

    The diversity and function of sourdough starter microbiomes

    Elizabeth A Landis, Angela M Oliverio ... Benjamin E Wolfe
    In the most comprehensive survey of sourdough starter biodiversity, this work identifies processes that control the diversity and function of sourdough microbiomes at a continental scale.
    1. Neuroscience

    Thalamocortical Synapses: Like a clock in the rabbit's visual cortex

    Frédéric Chavane, Diego Contreras
    Three rules govern the connectivity between neurons in the thalamus and inhibitory neurons in the visual cortex of rabbits.
    Version of Record
    Insight

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