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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites

    Peter Major et al.
    Transporters shared by fungal intracellular parasites provide new insights into the evolution of nucleotide and energy parasitism.
    1. Ecology

    Benefits of jasmonate-dependent defenses against vertebrate herbivores in nature

    Ricardo AR Machado et al.
    Uncovering an link between plant defense signaling and vertebrate feeding behavior suggests that large browsers may exert strong selection pressure on jasmonate-dependent secondary metabolites.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes

    Benjamin D Hobson et al.
    Although puromycin staining is often used to examine subcellular translation, puromycin-labeled proteins are rapidly released from ribosomes even in the presence of elongation inhibitors, which may confound translation site localization.
    1. Cancer Biology
    2. Cell Biology

    LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells

    Limian Cao et al.
    A c-Myc-transcribed long noncoding RNA namely LAST (LncRNA-assisted stabilization of transcripts) collaborates with a cellular factor CNBP to promote the stability of CCND1/cyclin D1 mRNA post-transcriptionally, ensuring the proper G1/Sphase transition of the cell cycle.
    1. Structural Biology and Molecular Biophysics

    Routine single particle CryoEM sample and grid characterization by tomography

    Alex J Noble et al.
    Fiducial-less tomography on single particle cryoEM samples reveals that most particles are adsorbed to the air-water interface and allows for researchers to diagnose and solve sample, grid, ice thickness, collection, and processing issues.
    1. Cancer Biology

    Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

    Hao Zhang et al.
    The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
    1. Structural Biology and Molecular Biophysics

    A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

    Andrea Saponaro et al.
    Cell-penetrating peptide drugs prevent adrenergic regulation of pacemaker channels without altering the overall response of the cell to cAMP.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Medicine

    Lack of airway submucosal glands impairs respiratory host defenses

    Lynda S Ostedgaard et al.
    Submucosal glands are critical for two key respiratory host defenses, bactericidal activity and mucociliary transport, in an animal model that has lungs like humans.
    1. Developmental Biology

    Essential role for SUN5 in anchoring sperm head to the tail

    Yongliang Shang et al.
    SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.