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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

    Ivan Kadurin et al.
    Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López et al.
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
    1. Neuroscience

    A corticostriatal deficit promotes temporal distortion of automatic action in ageing

    Miriam Matamales et al.
    Acquisition of behavioral sequences in normally aged mice involves short and unusually fast patterns of action, some of which are reproduced by striatal circuitry manipulations in young mice and can be transitorily restored through action-related feedback.
    1. Neuroscience

    Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats

    Briac Halbout et al.
    Inhibiting ventral tegmental dopamine neurons, or their inputs to nucleus accumbens, disrupts cue-motivated reward seeking in a manner that depends on the microstructure of behavior.
    1. Biochemistry and Chemical Biology

    A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

    Marisa D Ruehle et al.
    During initiation factor-independent RNA structure-driven translation initiation, a flexible RNA element drives the movement of a viral IRES through the ribosome's tRNA binding sites and promotes tRNA binding.
    1. Biochemistry and Chemical Biology

    Ribosomes slide on lysine-encoding homopolymeric A stretches

    Kristin S Koutmou et al.
    Ribosomes undergo an unanticipated movement (‘sliding’) while translating homopolymeric A sequences, which provides a biochemical rationale for the observation that iterated AAA codons are under-represented in gene-coding sequences.
    1. Ecology
    2. Neuroscience

    Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats

    Youna Vandaele et al.
    In a drug choice setting, rats’ preference is initially driven by deliberative processes but shifts to more automatic selection processes after extended training, in accordance with the sequential choice model.
    1. Cancer Biology

    Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

    Qiaoling Liu et al.
    EXOSC1 acts as an endogenous source of mutation inkidney renalclear cell carcinoma via cleaving single-stranded DNA.
    1. Cancer Biology
    2. Genetics and Genomics

    Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

    Annie Wai Yeeng Chai et al.
    Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.