6,518 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

    Zhe Zhang et al.
    The GEF activity of Rabex-5 is weakly autoinhibited by its CC domain and activated by Rabaptin-5 and the two proteins work concertedly to activate Rab5.
    1. Microbiology and Infectious Disease

    Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

    Toon Swings et al.
    Population mutation rates are highly flexible and evolvable under extreme stress conditions, matching changes in selective pressure to avoid extinction of the entire population.
    1. Cell Biology
    2. Computational and Systems Biology

    Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

    Miriam Bracha Ginzberg et al.
    Cells employ two strategies, adjusting both their cell cycle lengths and their growth rates in a size-dependent manner, to correct aberrations in cell size.
    1. Neuroscience

    Acoustic duetting in Drosophila virilis relies on the integration of auditory and tactile signals

    Kelly M LaRue et al.
    Quantitative behavioral assays and modeling show that acoustic duetting in Drosophila during courtship relies on the detection of precisely timed cues via multiple sensory channels.
    1. Genetics and Genomics
    2. Plant Biology

    Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

    Mark McMullan et al.
    Hybridization and introgression blur species boundaries and broaden genetic diversity available for adaptation; and widespread introgression underpins the evolution of races of the generalist pathogen Albugo candida that specialise on different host plant species.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses

    Matthew D Pauly et al.
    A new assay for specific mutational classes provides preciseestimates of the mutation rates and mutational bias for influenza A viruses.
    1. Biochemistry and Chemical Biology

    Measurement of average decoding rates of the 61 sense codons in vivo

    Justin Gardin et al.
    The translation rates of each yeast codon have been measured in both the A and P sites of the ribosome.
    1. Evolutionary Biology

    Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

    Fabien Duveau et al.
    The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    Work minimization accounts for footfall phasing in slow quadrupedal gaits

    James R Usherwood, Zoe T Self Davies
    The range of footfall patterns seen in walking amphibians, reptiles and mammals, including hippopotamus, horse and (inverted) sloth, are consistent with simple principles of mechanical work minimization.
    1. Structural Biology and Molecular Biophysics

    The near-atomic cryoEM structure of a flexible filamentous plant virus shows homology of its coat protein with nucleoproteins of animal viruses

    Xabier Agirrezabala et al.
    The high-resolution structure of a filamentous flexible plant virus shows that there is structural homology between its coat protein and the nucleoproteins of an unrelated group of enveloped RNA animal viruses.

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