109 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study

    Kennedy Lushasi, Kirstyn Brunker ... Katie Hampson
    Contact tracing data reveal how a One Health approach underpinned by dog vaccination interrupts rabies transmission in reservoir populations removing the risk to humans, while virus genome data highlight the importance of surveillance and sustained dog vaccination in connected populations.
    1. Neuroscience

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Aixin Zhang, Lei Jin ... Xiaoyin Chen
    Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
    1. Neuroscience

    A whole-brain connectivity map of mouse insular cortex

    Daniel A Gehrlach, Caroline Weiand ... Nadine Gogolla
    Whole-brain in- and outputs of inhibitory and excitatory neurons located in distinct subregions of the mouse insular cortex were mapped using viral-tracing strategies.
    1. Neuroscience

    Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions

    Jason R Klug, Max D Engelhardt ... Xin Jin
    A brain-wide mapping of the direct inputs to striatal cholinergic and parvalbumin interneurons reveals connectivity differences and implies their distinct roles in regulating striatal function.
    1. Neuroscience

    Postsynaptic cell type and synaptic distance do not determine efficiency of monosynaptic rabies virus spread measured at synaptic resolution

    Maribel Patiño, Willian N Lagos ... Edward M Callaway
    Under typical monosynaptic rabies tracing conditions about 40% of first-order presynaptic synapses to cortical neurons are labeled and spread efficiency does not vary depending on the distance of synapses to the cell body, across dendrite types, or starter neuron types.
    1. Neuroscience

    Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

    Remi Ronzano, Sophie Skarlatou ... Marco Beato
    Multiple trans-synaptic tracing methods reveal that there is no spatial segregation between flexor and extensor premotor interneurons in the lumbar spinal cord.
    1. Neuroscience

    Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination

    Edward Stanek IV, Steven Cheng ... Fan Wang
    Retrograde tracing of the neural circuits that control movement of the jaw and tongue reveals how shared premotor neurons help to ensure coordinated muscle activity.
    1. Neuroscience

    Specific and comprehensive genetic targeting reveals brain-wide distribution and synaptic input patterns of GABAergic axo-axonic interneurons

    Ricardo Raudales, Gukhan Kim ... Z Josh Huang
    A lineage-based intersectional genetic approach reveals brain-wide distribution and input connectivity of axo-axonic interneuron cells and establishes experimental access to study the circuit function of a ground truth cell type.
    1. Neuroscience

    Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

    Remi Ronzano, Camille Lancelin ... Marco Beato
    Populations of spinal cord neurons innervate motoneurons controlling local and distant synergist and antagonist muscles.
    1. Neuroscience

    Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells

    Kevin Beier
    A modified viral strategy reveals that ventral tegmental area dopamine cells receive substantial inputs from local sources, including distributed GABAergic and serotonergic inputs from the midbrain as well as extensive inputs from other midbrain dopamine cells.

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