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4,193 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

    Amrita Rai et al.
    A human three-helix Rab-binding domain can potentially bind to two Rab proteins simultaneously with different affinities at binding sites generated by gene duplication.
    1. Biochemistry and Chemical Biology

    PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

    Kerryn Berndsen et al.
    PPM1H protein phosphatase dephosphorylates Rab proteins modulating LRRK2 signalling.
    1. Structural Biology and Molecular Biophysics

    Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

    Jeffrey S Iwig et al.
    A key activator of Ras signaling adopts an autoinhibited, dimeric conformation that is activated by membrane and calcium binding.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle

    Yunsheng Cheng et al.
    Experiments in C. elegans reveal how synaptotagmin and Rab3, the 'yin and yang' of synapses, control whether transmitter vesicles remain docked at the presynaptic membrane or release their contents into the synapse.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

    Maja Šolman et al.
    Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

    Lars Langemeyer et al.
    Analysis of multiple guanine exchange factors shows that Rab activation can occur via a number of mechanistically distinct GDP-release pathways.
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Martin Steger et al.
    Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.
    1. Cell Biology

    Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

    Koji Yamano et al.
    Two GAP proteins bound to mitochondria regulate the enyzme Rab7, and thereby the expansion of the isolation membrane during mitophagy, downstream of PINK1 and Parkin, two proteins that are mutated in familial Parkinson's disease.
    1. Cell Biology
    2. Plant Biology

    Integration of two RAB5 groups during endosomal transport in plants

    Emi Ito et al.
    Plant-unique RAB5 effector 2 (PUF2) is an effector of plant-unique ARA6, which plays a key role in plant endosomal transport, integrating functions of the two plant RAB5 groups by an unprecedented mechanism.

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