388 results found
    1. Developmental Biology
    2. Neuroscience

    Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia

    Xin Heng et al.
    Genome-wide transcriptional profiling and genetic analyses reveal conserved mechanisms underlying the generation of neocortical basal radial glia and cerebellar Bergmann glia.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

    Shuguang Yu, Jie He
    The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
    1. Developmental Biology
    2. Neuroscience

    Radial glia regulate vascular patterning around the developing spinal cord

    Ryota L Matsuoka et al.
    Identification of a novel role for central nervous system-resident progenitors in the patterning of the vascular network around the developing spinal cord.
    1. Developmental Biology
    2. Neuroscience

    Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth

    Parthiv Haldipur et al.
    The mesenchyme surrounding the developing brain plays a significant role in controlling the fundamental growth and patterning of the cerebellum, and misregulation of this signalling can lead to important neurodevelopmental disorders.
    1. Neuroscience

    Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain

    Naoyuki Matsumoto et al.
    FGF signaling is crucial for gyrus formation, proliferation of outer radial glial cells and expansion of upper layers of the cerebral cortex in gyrencephalic mammals.
    1. Neuroscience

    Neurogliaform cortical interneurons derive from cells in the preoptic area

    Mathieu Niquille et al.
    In vivo genetic lineage-tracing reveals the developmental trajectory of neurogliaform cells, the main effectors of a powerful inhibitory motif in the neocortex.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

    Rongbo Li et al.
    Lineage tracing using a knockin Pdgfra-rtTA tool indicates distinct contributions of this cell lineage to myofibroblasts in normal development, fibrosis and bronchopulmonary dysplasia models.
    1. Structural Biology and Molecular Biophysics

    Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh

    SeCheol Oh, Olga Boudker
    Sodium ions control the rates of both substrate binding and dissociation of an archaeal homologue of glutamate transporters in a manner that minimizes binding intermediates and maximizes transport efficiency.
    1. Developmental Biology
    2. Neuroscience

    A novel perivascular cell population in the zebrafish brain

    Marina Venero Galanternik et al.
    A new brain perivascular cell type in the zebrafish related to mammalian Fluorescent Granular Perithelial (FGP) cells emerges directly from endothelium during early development.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

    Matthias Lübbert et al.
    A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.

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