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The identification of a SUMO E3 ligase engaged in lncRNA transcription, subsequently leading to target-directed small RNA degradation, reveals an unexplored layer of regulatory mechanisms within small RNA-directed chromatin regulation.

A series of compounds were synthesized and demonstrated to form a specific covalent bond with His64 of CAIX, an anticancer target, a strategy applicable to any drug design project.

A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.

Mitochondrial proteins Nfu1 and BolA3 mediate the transfer of preformed [4Fe-4S] clusters within the mitochondria to recipient proteins to shield clusters from oxidative damage during transfer.

The Ryanodine receptor type 1 calcium channels play a critical role in age-related muscle function loss.

Paracellular, trans-tight junction channels, which communicate between two extracellular compartments without crossing the plasma membrane, are a new class of ion channel with unitary behaviors similar to traditional transmembrane channels.

Starfish feed by everting their stomach out of their mouth over prey and, interestingly, this unusual feeding mechanism is inhibited by substances similar to hormones that regulate feeding in humans.

The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.