203 results found
    1. Neuroscience

    Foggy perception slows us down

    Paolo Pretto, Jean-Pierre Bresciani ... Heinrich H Bülthoff
    Virtual reality experiments show that motorists slow down when driving in fog, but they speed up when visibility is reduced equally at all distances.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion

    Meghan M McLean, Yong Chang ... Reid C Johnson
    The structure of the recombination complex responsible for flagellar antigen switching in Salmonella enterica, and the mechanism that regulates the site-specific DNA inversion reaction, have been determined.
    1. Chromosomes and Gene Expression

    The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

    Steven Henikoff, Srinivas Ramachandran ... Jorja G Henikoff
    A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
    1. Plant Biology

    Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases

    Yinwei Cheng, Wenjiao Zhu ... Xuelu Wang
    Brassinosteroids signal through a pathway involving GSK3-like kinases and the WER-GL3/EGL3-TTG1 transcription factor complex to determine the fate of cells in the root epidermis.
    1. Cell Biology

    Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

    Satoshi Tsunoda, Edward Avezov ... David Ron
    Adapting a cytosolic enzyme that breaks down glutathione to function in the lumen of the endoplasmic reticulum challenges the long-held view that reduced glutathione fuels disulfide rearrangements during protein folding.
    1. Neuroscience

    Reconceiving the hippocampal map as a topological template

    Yuri Dabaghian, Vicky L Brandt, Loren M Frank
    Empirical evidence suggests that the hippocampus constructs maps of spatial environments based on the relative locations of places (i.e., topology), rather than absolute distances and coordinates (i.e., geometry).
    1. Developmental Biology

    Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

    Lauren LeBon, Tom V Lee ... Michael B Elowitz
    Fringe proteins modulate cis inhibitory, same-cell interactions between the Notch receptor and its ligands to control whether, and in which direction, cells can signal to one another.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A combined quantitative mass spectrometry and electron microscopy analysis of ribosomal 30S subunit assembly in E. coli

    Dipali G Sashital, Candacia A Greeman ... James R Williamson
    Comprehensive structural and compositional characterization of the in vivo 30S ribosomal assembly landscape reveals parallel pathways for 3′-domain formation and a previously unknown role for the assembly factor RimP.
    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen, Diancai Cai ... David L Glanzman
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of drug resistance in clinical isolates of Candida albicans

    Christopher B Ford, Jason M Funt ... Aviv Regev
    Loss-of-heterozygosity mutations, but not aneuploidies, are linked to the evolution of drug resistance in Candida albicans isolated from immunocompromised patients.

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