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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

    Paul Yourik, Colin Echeverría Aitken ... Jon R Lorsch
    Eukaryotic translation initiation factor 4A is stimulated by the ribosomal pre-initiation complex and promotes the recruitment of mRNAs regardless of their degree of structure.
    1. Cancer Biology

    Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

    Eugine Lee, Zeda Zhang ... Charles L. Sawyers
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Evolutionary Biology

    The age of Homo naledi and associated sediments in the Rising Star Cave, South Africa

    Paul HGM Dirks, Eric M Roberts ... Lee R Berger
    Independent dating techniques have established that the H. naledi fossils are between 236 and 335 thousand years old, indicating that small-brained hominins with relatively primitive body shapes co-existed with our early ancestors in Africa.
    1. Neuroscience

    Cell type-specific long-range connections of basal forebrain circuit

    Johnny Phong Do, Min Xu ... Yang Dan
    Whole-brain mapping of the basal forebrain circuits reveals a connection diagram with highly convergent inputs and divergent outputs.
    1. Neuroscience

    Specific Sensitivity to Rare and Extreme Events: Quasi-Complete Black Swan Avoidance vs Partial Jackpot Seeking in Rat Decision-Making

    Mickaël Degoulet, Louis-Matis Willem ... Patrick A Pintus
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Evolutionary Biology
    2. Genetics and Genomics

    A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male wing dimorphism

    Binshuang Li, Ryan D Bickel ... Jennifer A Brisson
    The application of long-read sequencing to the pea aphid wing dimorphism system reveals genomic structural divergence as a genetic mechanism of adaptation.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants

    Panagiotis Sapountzis, Mariya Zhukova ... Jacobus J Boomsma
    Domestication of endosymbiotic Mollicutes may have resolved nitrogen-recycling challenges for attine ants and enabled the evolutionary derived leaf-cutting ants to fully exploit their herbivorous niches.
    1. Neuroscience

    An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons

    Mofida Abdelmageed, Premkumar Palanisamy ... Anirban Paul
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak, Lindsey Fong ... Vincent J Lynch
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.