A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.

Combining experimental and theoretical approaches reveals the interplay between optogenetic manipulation and recurrent interactions in mouse cortex.

A computational framework and analysis of rodent CA1 data reveals that theta oscillations sequentially sweep through the past, present, and future at a spatial scale that varies with the characteristic speed of the animal.

GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.

μCT-aided study illuminates the cranial endoskeleton and interrelationships of the Permian actinopterygian †Brachydegma, which is now excluded from crown neopterygians despite exhibiting a double jaw joint.

A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.

A method has been developed to characterize the expressed biochemical activities of gut microbial communities using retrievable, microscopic, fluorescent-labeled glass beads containing chemically bound surface biomolecules.

By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.

Intracellular protein gradients, which are formed by the combined action of cytoplasmic diffusion and cortical transport toward the cell pole, are solely determined by cell shape.

The neural representation of position in the medial entorhinal cortex may be stabilized by synaptic connectivity across modules, which enforces coherent updates in their states.