A multi-cohort analysis of 2,500 gut microbiomes and five major diseases discovers that disease-microbiome associations display specific age-centric trends, with diseases characterized by age-centric trends of species gain/loss.
Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.
The V600E mutation in BRAF is a cancer hot spot because it opens the activation segment through destabilization of autoinhibitory interactions, but it does not significantly impair folding of the inactive or active kinase domain.
Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
Jakub Witold Bubnicki, Marcin Churski ... Dries PJ Kuijper
The spatial interactions between humans, large carnivores and herbivores cascade down in a complex but predictable way to lower trophic levels affecting regeneration of tree species in a temperate forest.
Luca Casiraghi, Francesco Mambretti ... Tommaso Bellini
A variant of SELEX introduced here to induce abiotic evolution in a molecular system enables to observe and study speciation, the nature of fitness, and the interplay between use of resources and interactions between individuals.
Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.
Amanda J Lea, Christopher M Vockley ... Jenny Tung
mSTARR-seq identifies regions of the genome where DNA methylation causally impacts gene expression, providing a map of which epigenetic marks may influence trait variation.
