241 results found
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen et al.
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
  1. Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

    Diana Herrera-Perez et al.
    An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals.
    1. Neuroscience

    Context-dependent signaling of coincident auditory and visual events in primary visual cortex

    Thomas Deneux et al.
    Abrupt sounds boost coincident visual cortex responses which could help localization of sudden audio-visual events.
    1. Neuroscience

    Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

    Samuel JD Lawrence et al.
    Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.
    1. Neuroscience

    Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats

    Caesar M Hernandez et al.
    Optogenetic approaches in young and aged rats define multiple roles for basolateral amygdala in guiding intertemporal choice, and show that these roles change across the lifespan.
    1. Neuroscience

    Unimodal statistical learning produces multimodal object-like representations

    Gábor Lengyel et al.
    Mere exposure to scenes with statistical contingencies in the visual or haptic modality alone allows participants to decompose scenes into object-like multimodal representations.
    1. Neuroscience

    Precise excitation-inhibition balance controls gain and timing in the hippocampus

    Aanchal Bhatia et al.
    Delayed inhibition precisely balances excitation from arbitrary combinations of CA3 neurons and controls the gain of CA1 output by reducing inhibitory delay with increasing excitation.
    1. Neuroscience

    Neural mediation of greed personality trait on economic risk-taking

    Weiwei Li et al.
    Greed personality trait is associated with behavioral loss aversion via the mediation of the neural loss aversion signal in the medial orbitofrontal cortex.
    1. Neuroscience

    Thalamocortical synapses in the cat visual system in vivo are weak and unreliable

    Madineh Sedigh-Sarvestani et al.
    A characterization of LGN-V1 synaptic transmission properties demonstrates thalamocortical synapses in vivo are weak and unreliable, but biologically constrained models show they efficiently drive cortex.
    1. Neuroscience

    Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

    Hannah L Payne et al.
    Patterned optogenetic stimulation and analysis of neural activity provide convergent evidence that cerebellar Purkinje cells drive eye movements with a rapid rate code, without an additional contribution of spike irregularity.

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