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    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    1. Ecology
    2. Evolutionary Biology

    Understanding the evolution of multiple drug resistance in structured populations

    David V McLeod, Sylvain Gandon
    The evolution of multidrug resistance can be most easily understood by focusing upon the dynamical equations of linkage disequilibrium.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

    Matthew L Schwartz, Daniel P Nickerson ... Alexey J Merz
    Sec17 is shown to have divergent effects on pre-fusion SNARE complex activity, depending on the state of SNARE zippering and HOPS, an SM-tether complex, controls the outcome of Sec17-SNARE engagement.
    1. Cell Biology
    2. Neuroscience

    MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

    Andrea Toledo, Mathieu Letellier ... Olivier Thoumine
    MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.
    1. Developmental Biology

    Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

    Andrew Liu, Jessica O’Connell ... Richard W Carthew
    Two atypical cadherins regulate organ growth by tuning the coupling of cell cycle duration to organ size.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Coordination of two opposite flagella allows high-speed swimming and active turning of individual zoospores

    Quang D Tran, Eric Galiana ... Xavier Noblin
    Coordinated actions of two opposite flagella control speed and change direction of plant pathogen Phytophthora zoospores, in which the anterior flagellum is the main motor to generate thrust and spontaneously switch from reciprocal beating to breaststrokes to reorient its body.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

    Sudipta Mondal, Priyadarshan Kinatukara ... Rajan Sankaranarayanan
    DIP2 is a conserved protein across fungi and animals that regulates specific diacylglycerol pools by diverting them to storage lipid biosynthesis to enable cellular homeostasis and adaptations.
    1. Neuroscience

    Homeostatic reinforcement learning for integrating reward collection and physiological stability

    Mehdi Keramati, Boris Gutkin
    A mathematical model built around the assumption that the desire to maintain internal homeostasis drives the behavior of animals, by affecting their learning processes, can explain many real-world behaviors, including some that might otherwise appear irrational.
    1. Neuroscience

    A naturalistic environment to study visual cognition in unrestrained monkeys

    Georgin Jacob, Harish Katti ... SP Arun
    A novel naturalistic environment with a touchscreen enables high-quality eye tracking for studying visual cognition in monkeys, and allows naive monkeys to learn complex tasks through a combination of social observation of trained monkeys and trial-and-error learning.
    1. Physics of Living Systems

    The exchange dynamics of biomolecular condensates

    Yaojun Zhang, Andrew GT Pyo ... Ned S Wingreen
    Exchange of components between biomolecular condensates and the surrounding dilute phase can be limited by dense-phase mixing, dilute-phase influx, or by the slow incorporation of molecules through the condensate interface.