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    1. Developmental Biology
    2. Neuroscience

    Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system

    Orkun Akin, S Lawrence Zipursky
    Direct observation in the developing fly brain indicates that the response of a growth cone in a gradient of a guidance cue is adhesion to the source of the cue rather than attraction by the gradient.
    1. Neuroscience

    Asymmetric ON-OFF processing of visual motion cancels variability induced by the structure of natural scenes

    Juyue Chen, Holly B Mandel ... Damon A Clark
    The fruit fly estimates visual motion by incorporating ON-OFF asymmetric processing that only improves performance when stimuli have light-dark asymmetries matched to natural scenes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sweepstakes reproductive success via pervasive and recurrent selective sweeps

    Einar Árnason, Jere Koskela ... Bjarki Eldon
    Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
    1. Genetics and Genomics

    The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

    Monica Sanchez-Contreras, Mariya T Sweetwyne ... Scott R Kennedy
    The accumulation of somatic mutations during aging is not uniform across tissue types and, in addition, shows significant variability in the source of mutation that can be modified by small molecule interventions.
    1. Physics of Living Systems

    Overtone focusing in biphonic tuvan throat singing

    Christopher Bergevin, Chandan Narayan ... Brad Story
    In light of the mysteries underlying the biphonic nature of Tuvan throat song, information from multiple modalities is combined to explain how this remarkable phenomenon is achieved biomechanically.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The whale shark genome reveals patterns of vertebrate gene family evolution

    Milton Tan, Anthony K Redmond ... Timothy Read
    The new whale shark genome assembly represents the best gapless chondrichthyan genome assembly yet, and comparative genomic analyses provide insights into the evolution of vertebrate genome origins, immunity, and gigantism.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet, Remi Peyraud ... Sylvain Raffaele
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

    Ravi Vijayvargia, Raquel Epand ... Ihn Sik Seong
    Structural and biochemical analysis of full-length huntingtin protein illuminates the impact of the polyglutamine region on its structure and function.
    1. Evolutionary Biology

    Diversification dynamics in the Neotropics through time, clades, and biogeographic regions

    Andrea S Meseguer, Alice Michel ... Fabien L Condamine
    Neotropical outstanding biodiversity emerged from sustained rates of species accumulation over time, although, for some periods, tetrapods were less successful than plants in keeping pace with a changing environment.
    1. Evolutionary Biology
    2. Neuroscience

    A brain-wide analysis maps structural evolution to distinct anatomical module

    Robert A Kozol, Andrew J Conith ... Erik R Duboue
    Genetic analyses reveal that neuroanatomical areas that are developmentally related co-evolve with one another.