Rectangular order perturbations generalize sign epistasis, capture global aspects of fitness landscapes, and clarify how rank order approaches relate.

A new mathematical approach can infer higher order genetic interactions from pairwise fitness comparisons between genotypes.

Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.

Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.

The Ran GTPase plays a role in defining the physical properties of the nuclear pore complex transport channel by remodeling the binding interactions of importin-β with the nucleoporin Nup153 at the nuclear face of the pore.

Social information is a process encompassing information acquisition, application and exploitation that is constrained by an individual’s social, behavioural and demographic phenotype.

Attention reduces noise correlations through enhancing inhibitory feedback in cortical networks.

Multistability and regime shifts are common and species diversity is high in microbial communities when nutrient supplies are balanced and competing species have different stoichiometries of essential nutrients.

Gene flow analysis reveals that the genomes of most sub-Saharan populations are the result of recent historical admixture events.

Genome neighborhood networks provide an efficient large-scale approach to mine metabolic pathway context for entire families of proteins and enzymes.