4,364 results found
    1. Evolutionary Biology

    Rank orders and signed interactions in evolutionary biology

    Kristina Crona
    Rectangular order perturbations generalize sign epistasis, capture global aspects of fitness landscapes, and clarify how rank order approaches relate.
    1. Computational and Systems Biology

    Inferring genetic interactions from comparative fitness data

    Kristina Crona et al.
    A new mathematical approach can infer higher order genetic interactions from pairwise fitness comparisons between genotypes.
    1. Cancer Biology
    2. Genetics and Genomics

    Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

    Timour Baslan et al.
    Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf et al.
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

    Alan R Lowe et al.
    The Ran GTPase plays a role in defining the physical properties of the nuclear pore complex transport channel by remodeling the binding interactions of importin-β with the nucleoporin Nup153 at the nuclear face of the pore.
    1. Ecology

    Sequential phenotypic constraints on social information use in wild baboons

    Alecia J Carter et al.
    Social information is a process encompassing information acquisition, application and exploitation that is constrained by an individual’s social, behavioural and demographic phenotype.
    1. Neuroscience

    Attentional modulation of neuronal variability in circuit models of cortex

    Tatjana Kanashiro et al.
    Attention reduces noise correlations through enhancing inhibitory feedback in cortical networks.
    1. Ecology

    Multistability and regime shifts in microbial communities explained by competition for essential nutrients

    Veronika Dubinkina et al.
    Multistability and regime shifts are common and species diversity is high in microbial communities when nutrient supplies are balanced and competing species have different stoichiometries of essential nutrients.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Admixture into and within sub-Saharan Africa

    George BJ Busby et al.
    Gene flow analysis reveals that the genomes of most sub-Saharan populations are the result of recent historical admixture events.
    1. Biochemistry and Chemical Biology

    Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks

    Suwen Zhao et al.
    Genome neighborhood networks provide an efficient large-scale approach to mine metabolic pathway context for entire families of proteins and enzymes.

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