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    1. Neuroscience

    CaImAn an open source tool for scalable calcium imaging data analysis

    Andrea Giovannucci, Johannes Friedrich ... Eftychios A Pnevmatikakis
    CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Neuroscience

    Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex

    Marie-Sophie H van der Goes, Jakob Voigts ... Mark T Harnett
    Dual site recordings of mouse anterodorsal thalamic nucleus and retrosplenial cortex reveal near 0-ms lag between the head direction representations of the two regions after cue rotations and correlated drift in darkness.
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan M Shugarts Devanapally, Aishwarya Sathya ... Antony M Jose
    Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes in gene expression.
    1. Neuroscience

    Emergence and function of cortical offset responses in sound termination detection

    Magdalena Solyga, Tania Rinaldi Barkat
    Cortical offset responses are not only inherited from the periphery but also amplified and de novo generated, and preventing them decreases the ability to detect sound termination.
    1. Developmental Biology
    2. Genetics and Genomics

    Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

    Mahdi Moradi Marjaneh, Edwin P Kirk ... Richard P Harvey
    A high-resolution picture of genetic complexity and network perturbations underlying cardiac inter-atrial septal dysmorphology associated with patent foramen ovale, a common human congenital anomaly, using quantitative trait locus mapping, genome sequencing, and transcriptomics in a mouse model.
    1. Neuroscience

    Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input

    Zohre Azimi, Ruxandra Barzan ... Dirk Jancke
    Serotonergic input to visual cortex controls ongoing and evoked activity in a separable manner via distinct receptor pathways.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

    Hamish W King, Robert J Klose
    The chromatin remodeller BRG1 is recruited to pluripotency-associated gene regulatory elements by the pioneer transcription factor OCT4 to support further transcription factor binding and gene regulation.
    1. Genetics and Genomics

    Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies

    Jonci Nikolai Wolff, Neil J Gemmell ... Damian K Dowling
    Mitochondrial genomes harbor male-fertility-reducing mutations that can be harnessed to control population viability as a novel approach to control economic and environmental pests.
    1. Neuroscience

    Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

    Sahab Arinrad, Constanze Depp ... Klaus-Armin Nave
    Loss of myelin integrity in the mouse forebrain perturbs executive functions, assessed by tests requiring normal motor performance.