1,183 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Listeria monocytogenes cell-to-cell spread in epithelia is heterogeneous and dominated by rare pioneer bacteria

    Fabian E Ortega, Elena F Koslover, Julie A Theriot
    The pathogenic bacterium Listeria monocytogenes spreads infection using a two-tiered strategy, where most bacteria spread locally but a few 'pioneers' move further, increasing the likelihood of a persistent infection.
    1. Microbiology and Infectious Disease

    Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes

    William J Watterson, Melikhan Tanyeri ... Savaş Tay
    High-throughput droplet-based cultivation of gut microbes reduces biases of traditional cultivation strategies and thereby enables detection of difficult-to-culture organisms, which is required in applications such as antibiotic screening.
    1. Evolutionary Biology

    Spatio-temporal control of mutualism in legumes helps spread symbiotic nitrogen fixation

    Benoit Daubech, Philippe Remigi ... Delphine Capela
    Experiments and mathematical modelling show that rare nitrogen fixing symbionts invade a population dominated by non-fixing bacteria across plant generations, above a threshold of a combination of ecological factors.
    1. Medicine
    2. Microbiology and Infectious Disease

    The effect of combining antibiotics on resistance: A systematic review and meta-analysis

    Berit Siedentop, Viacheslav N Kachalov ... Sebastian Bonhoeffer
    A systematic review shows no evidence of harm or benefit of antibiotic combinations on resistance evolution as clinical data lack statistical power to draw definitive conclusions, highlighting a knowledge gap.
    1. Physics of Living Systems

    Interplay of surface interaction and magnetic torque in single-cell motion of magnetotactic bacteria in microfluidic confinement

    Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp
    Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Identical sequences found in distant genomes reveal frequent horizontal transfer across the bacterial domain

    Michael Sheinman, Ksenia Arkhipova ... Florian Massip
    Horizontal gene transfer between distantly related bacterial species is frequent and widespread and can be efficiently identified using alignment-free methods.
    1. Biochemistry and Chemical Biology

    A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer

    Ruben M Atilho, Gayan Mirihana Arachchilage ... Ronald R Breaker
    Many bacteria use a tiny riboswitch aptamer to sense the thiamin precursor HMP-PP to regulate the production of another thiamin precursor HET-P to efficiently biosynthesize this essential coenzyme.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants

    Panagiotis Sapountzis, Mariya Zhukova ... Jacobus J Boomsma
    Domestication of endosymbiotic Mollicutes may have resolved nitrogen-recycling challenges for attine ants and enabled the evolutionary derived leaf-cutting ants to fully exploit their herbivorous niches.
    1. Evolutionary Biology

    Antibacterial gene transfer across the tree of life

    Jason A Metcalf, Lisa J Funkhouser-Jones ... Seth R Bordenstein
    Parallel horizontal gene transfer has spread a bacteriolytic gene family to all domains of life, and has bestowed a niche-transcending adaptation in recipients that must deploy antibacterial molecules to survive in a bacterial world.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunodeficiency: Back from the brink of obscurity

    Donald C Vinh
    A mutation in a transcription factor makes people susceptible to Trophyrema whippelii, the bacterium that causes a rare condition called Whipple's disease.
    Version of Record
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