5,496 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

    Rachel A Battaglia et al.
    GFAP protein carries a distinct post-translational modification signature that facilitates its pathogenic accumulation and aggregation in astrocytes of patients who succumb to Alexander Disease very early in life.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diverse functions of homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence

    Pavan Vedula et al.
    CRISPR/Cas9 gene editing in mice reveals that diverse functions of actin isoforms are defined by their nucleotide, rather than their amino acid sequence, suggesting a novel mechanism of nucleotide-dependent protein regulation in eukaryotic genomes.
    1. Developmental Biology

    NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

    Romaric Bouveret et al.
    Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.
    1. Structural Biology and Molecular Biophysics

    Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

    Wenjuan Zhang et al.
    Cryo-EM structures of heparin-induced tau filaments differ from those observed in neurodegenerative disease, illustrating their structural versatility, and prompting questions about the relevance of in vitro amyloid models.
    1. Cell Biology
    2. Developmental Biology

    NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

    Lindsey Seldin et al.
    A newly identified microtubule binding activity of NuMA is required for orienting the mitotic spindle.
    1. Ecology

    Mammal communities are larger and more diverse in moderately developed areas

    Arielle Waldstein Parsons et al.
    Citizen science camera trapping showing suburban and wild areas maintain similar levels of mammalian diversity and relative abundance, challenging conventional thoughts about the impacts of urbanization on wildlife.
    1. Human Biology and Medicine
    2. Neuroscience

    Tissue Engineering: Building a better blood-brain barrier

    Courtney Lane-Donovan, Joachim Herz
    A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.
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    1. Evolutionary Biology

    Stem Cells: Getting to the heart of cardiovascular evolution in humans

    Alex Pollen, Bryan J Pavlovic
    Differences in the response of cardiomyocytes to oxygen deprivation in humans and chimpanzees may explain why humans are more prone to certain heart diseases.
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Immunodeficiency: Back from the brink of obscurity

    Donald C Vinh
    A mutation in a transcription factor makes people susceptible to Trophyrema whippelii, the bacterium that causes a rare condition called Whipple's disease.
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