11,397 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

    Amrita Rai et al.
    A human three-helix Rab-binding domain can potentially bind to two Rab proteins simultaneously with different affinities at binding sites generated by gene duplication.
    1. Neuroscience

    Vocalization–whisking coordination and multisensory integration of social signals in rat auditory cortex

    Rajnish P Rao et al.
    Snout-to-snout contact modulates the response of rat auditory cortex to calls from other animals, indicating that the multisensory nature of social interaction is directly represented in the rat brain.
    1. Structural Biology and Molecular Biophysics

    Binary architecture of the Nav1.2-β2 signaling complex

    Samir Das et al.
    X-ray crystallography reveals new conceptual insights into the location of the β2-subunit in the Nav channel signaling complex.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

    Xiao Ling Li et al.
    Discovery and initial characterization of a conserved small protein translated from a transcript annotated as a human long non-coding RNA.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

    Kevin D'hoe et al.
    Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.
    1. Structural Biology and Molecular Biophysics

    Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

    Jeffrey S Iwig et al.
    A key activator of Ras signaling adopts an autoinhibited, dimeric conformation that is activated by membrane and calcium binding.
    1. Neuroscience

    Structural development and dorsoventral maturation of the medial entorhinal cortex

    Saikat Ray, Michael Brecht
    The medial entorhinal cortex is important for spatial memory formation and matures from dorsal, where smaller spatial-scales are represented, to ventral, where larger spatial-scales are represented.
    1. Cancer Biology

    Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers

    Ganesh V Raj et al.
    A novel first-in-class small molecule (ERX-11) that interacts with and disrupts the interactome of the estrogen receptor (ER), blocks the growth of ER-positive breast cancers, including those that are resistant to currently approved hormonal agents.
  1. Meta-Research: Tracking the popularity and outcomes of all bioRxiv preprints

    Richard J Abdill, Ran Blekhman
    Data are reported for the monthly number of uploads to and downloads from bioRxiv, and for the number of preprints that are later published in peer-reviewed journals.
    1. Ecology

    Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

    J Graham Ruby et al.
    We are writing to respond to the comment by Dammann et al., 2019 on our article about aging in naked mole-rats (Ruby et al., 2018).

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