2,985 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq

    Julie L Aspden et al.
    Thousands of small Open Reading Frames are translated, and form two distinct classes based on their translational efficiency and bioinformatic indicators.
    1. Ecology

    Bleaching causes loss of disease resistance within the threatened coral species Acropora cervicornis

    Erinn M Muller et al.
    Standing genetic variation for disease resistance may be continuously lost during recurring warm water episodes because of widespread susceptibility of disease-resistant genotypes to bleaching and the independence between these two traits.
    1. Neuroscience

    Rhythmogenic Networks: The ins and outs of breathing

    Jan-Marino Ramirez et al.
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  1. Living Science: Teaching for the future

    Indira M Raman
    Reading and discussing classic papers can be an effective way of teaching graduate students how to learn the skills they will need for a career in research.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

    R Stefan Isaac et al.
    The inhibitory influence of nucleosomes on CRISPR-Cas9 is mitigated by nucleosomal DNA breathing and chromatin remodeling.
    1. Cell Biology
    2. Neuroscience

    Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

    Kentarou Baba et al.
    Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.
    1. Human Biology and Medicine
    2. Neuroscience

    Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome

    Valéry Matarazzo et al.
    Inhibition of serotonin transporter activity, by fluoxetine treatment, in early post-natal life induces persistent apnea in wild-type mice but restores normal breathing in Necdin-KO pups that reproduce breathing abnormalities observed in Prader-Willi syndrome.
  2. Peer Review: Searching for the one

    Helga Groll
    The views of peers are important when applying for a faculty position, but so are research plans and being a good 'fit'.
    1. Computational and Systems Biology

    Protein Overexpression: Reaching the limit

    Benedetta Bolognesi, Ben Lehner
    How many copies of a protein can be made before it becomes toxic to the cell?
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    1. Human Biology and Medicine

    Point of View: Strategies from UW-Madison for rescuing biomedical research in the US

    Judith Kimble et al.
    A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.

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