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    1. Computational and Systems Biology
    2. Evolutionary Biology

    Shearing in flow environment promotes evolution of social behavior in microbial populations

    Gurdip Uppal, Dervis Can Vural
    Shearing in fluid flow induces or enhances budding dispersal in microbial populations, resulting in stronger cooperative behavior.
    1. Neuroscience

    Anatomical and functional organization of the human substantia nigra and its connections

    Yu Zhang et al.
    The human substantia nigra can be parcellated into three subdivisions that subserve emotional, cognitive and somatomotor function.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay et al.
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Physics of Living Systems

    Plasticity of cell migration resulting from mechanochemical coupling

    Yuansheng Cao et al.
    Computational and experimental studies show that different migration modes of eukaryotic cells are the result of the interplay between signaling waves and cell mechanics.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

    Jean-Michel Arbona et al.
    The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.
    1. Developmental Biology

    Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions

    Sapthaswaran Veerapathiran et al.
    Wnt3 accomplishes long-range distribution by extracellular diffusion controlled by expression, tissue morphology, interactions with heparan sulfate proteoglycans, and co-receptor-mediated receptor binding to regulate brain development in zebrafish embryos.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke et al.
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A glucose-starvation response regulates the diffusion of macromolecules

    Ryan P Joyner et al.
    During stress conditions, eukaryotic cells dramatically alter their biophysical properties to regulate diffusion of macromolecules.
    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song et al.
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
    1. Neuroscience

    Neural precursors of decisions that matter—an ERP study of deliberate and arbitrary choice

    Uri Maoz et al.
    The readiness potential—a long-established neural precursor of voluntary action claimed to precede the onset of the conscious decision to move—is absent, or at least significantly reduced, for deliberate decisions.