548 results found
    1. Neuroscience

    Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

    Matthew CW Oswald et al.
    Reactive oxygen species, previously considered damaging agents linked to pathology, are required for normal neuronal plasticity, including adjustment of synaptic terminal size, maintenance of synaptic physiology and adaptive behavioural responses.
    1. Neuroscience

    SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans

    Xiaoyan Guo, L René García
    A protein called SIR-2.1 helps to protect worms from the effects of aging by regulating metabolic processes that would otherwise generate damaging reactive oxygen species.
    1. Cancer Biology

    Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

    Ernesto Pérez et al.
    The oncogenic RasV12 keeps cells mutant for the tumor suppressor scribble in an undead-like condition, which is required for an amplification loop that promotes tumorigenesis.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu et al.
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain

    L Shahul Hameed et al.
    Control of neural stem cells by reactive oxygen species (ROS) provides a link between systemic shifts in oxygen tension and neuronal regeneration, and suggests an evolutionary driving force for the inherent ability of newts to regenerate their brain cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Hold your breath!

    Katharina Lust, Joachim Wittbrodt
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    1. Cell Biology
    2. Genetics and Genomics

    Protein Homeostasis: How chloroplasts protect themselves from unfolded proteins

    Felix Kessler, Paolo Longoni
    A genetic screen has identified the first signaling component of the unfolded protein response in chloroplasts.
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    1. Ecology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns et al.
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Neuroscience

    Energy imbalance alters Ca2+ handling and excitability of POMC neurons

    Lars Paeger et al.
    The development of diet-dependent obesity results in the deterioration of calcium homeostasis in pro-opiomelanocortin-expressing neurons and impaired function of the same neurons.
    1. Neuroscience

    NPTX2 and cognitive dysfunction in Alzheimer’s Disease

    Mei-Fang Xiao et al.
    Dysfunction of pyramidal neuron-PV interneuron circuits contributes to cognitive failure in Alzheimer's disease.

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