552 results found
    1. Structural Biology and Molecular Biophysics

    Flexibility in PAM recognition expands DNA targeting in xCas9

    Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
    xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.
    1. Developmental Biology

    A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids

    Bin Zhu, Rui Wei ... Pei Liang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Human cerebellum and ventral tegmental area interact during extinction of learned fear

    Enzo Nio, Patrick Pais Pereira ... Dagmar Timmann
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K Alexander, Karina F Rodriguez ... Humphrey Hung-Chang Yao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Physics of Living Systems

    Cell-cycle and Age-Related Modulations of Mouse Chromosome Stiffness

    Ning Liu, Wenan Qiang ... Huanyu Qiao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    Junghoon Lee, Scot P Ouellette
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    A double dissociation between semantic and spatial cognition in visual to default network pathways

    Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
    Default mode network and visual cortex are connected via two parallel pathways that differentially respond to the processing of visual scenes and semantic information about objects, reflecting domain-specific organisation.
    1. Microbiology and Infectious Disease

    ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

    Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

    Yuqian Wang, Guibin Wang ... Xiangmin Lin
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability

    Jia-Ying Su, Yun-Lin Wang ... Chien-Ling Lin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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