Sarvenaz Sarabipour, Kurt Ballmer-Hofer, Kalina Hristova
A receptor for vascular endothelial growth factor forms dimers in the absence of its ligand, and ligand-binding leads to structural changes that result in increased kinase phosphorylation.
Sigrid Nachtergaele, Daniel M Whalen ... Rajat Rohatgi
A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.
Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.
Huaibin Chen, William M Marsiglia ... Moosa Mohammadi
A four-switch long-range allosteric network controls FGF receptor kinase conformational dynamics as well as activity and is applicable to other receptor tyrosine kinases.
Phylogenetic and computational methods reveal that at least two seasonal coronaviruses are evolving adaptively in the region of the viral spike protein exposed to the human humoral immune system.
Andrea Sánchez-Vallet, Raspudin Saleem-Batcha ... Jeroen R Mesters
Structural and biochemical analysis of a protein called Ecp6, which is produced by a tomato fungus, reveals how the protein prevents plants from launching an immune response to the chitin in fungal cell walls.
A toxin produced by the bacterium Bordetella pertussis preferentially binds to non-activated integrin complement receptor 3 outside of its ligand-binding I-domain and efficiently blocks downstream signaling of the integrin through elevation of cytosolic cAMP.
