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Page 2 of 211
    1. Biochemistry and Chemical Biology

    Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

    Victoria Juskaite et al.
    Ligand binding induces DDR1 kinase activity through recruitment of DDR1 receptors into signalling clusters in which phosphorylation occurs across different dimers.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Erin D Lew et al.
    Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.
    1. Plant Biology
    2. Developmental Biology

    Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling

    Xingyun Qi et al.
    The stomatal precursor cell uses autocrine peptide-receptor kinase signaling to self-inhibit its differentiation potential in order to ensure proper stomatal development on the plant epidermis.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

    Jie Li et al.
    Cryo-EM studies reveal structural basis for the activation, auto-inhibition and regulation of RET receptor tyrosine kinase.
    1. Cell Biology
    2. Neuroscience

    The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

    Jie Gao et al.
    Control of lipoprotein receptor protein levels at synapses by the E3 ubiquitin ligase IDOL is shown to be important for the plasticity of neuronal dendrites in vitro and learning and memory in mice.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

    Julia Santiago et al.
    A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

    Tanya S Freedman et al.
    Degradation of kinase LynA protects macrophages from activation unless cells sense a receptor-binding pathogen or inflammation
    1. Cell Biology
    2. Neuroscience

    The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons

    Eun Chan Park, Christopher Rongo
    The subcellular localization of the prolyl hydroxylase oxygen sensor in C. elegans neurons is regulated by p38 MAP kinase signaling.
    1. Plant Biology

    The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1

    Yangrong Cao et al.
    The chitin-triggered immune response is mediated by a LYK5 and CERK1 receptor complex in Arabidopsis.
    1. Cell Biology
    2. Plant Biology

    A receptor-like kinase mutant with absent endodermal diffusion barrier displays selective nutrient homeostasis defects

    Alexandre Pfister et al.
    The SCHENGEN3 protein is needed for the progression of isolated microdomains into a continuous band, which is necessary for the establishment of the major extracellular diffusion barrier in plant roots: the Casparian strip.