1,816 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
    1. Ecology

    Entomopathogenic nematodes increase predation success by inducing cadaver volatiles that attract healthy herbivores

    Xi Zhang et al.
    By changing the smell of their host, entomopathogenic nematodes attract future hosts and increase their predation success.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

    Edward A Partlow et al.
    Cryo-EM reveals how a protein called NECAP inactivates the AP2 clathrin adaptor complex through concerted engagement of two domains which confer specificity for membrane-activated and phosphorylated AP2.
    1. Developmental Biology

    Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish

    Craig T Jacobs, Peng Huang
    Genetic analyses combining photoconvertible cell signalling reporters with gain- and loss-of function manipulations reveal a novel role for Notch signalling in controlling Hedgehog response in neural progenitor cells.
    1. Neuroscience

    TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

    Bin Wu et al.
    Purkinje cells feature molecular heterogeneity that introduces differentiation in physiological properties between zebrin-identified cerebellar modules and thereby underlies the differential control on sensorimotor integration.
    1. Cell Biology

    Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction

    Matthew G Marzo et al.
    A mutagenesis screen in budding yeast sheds light on dynein regulation and function, and reveals the molecular basis for disease in patients suffering from neuropathies caused by dynein dysfunction.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Neuroscience

    HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

    Niklas Byczkowicz et al.
    The cAMP-HCN pathway can control action potential conduction velocity providing neuromodulators with the ability to tune energy consumption and temporal delays across axons in the brain.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

    Jinsheng Zhu et al.
    Genetic and biochemical analysis of two enzymes reveals that inositol pyrophosphate signaling molecules allow plants to sense and regulate cellular phosphate levels, and to take up more phosphate when needed.

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