Auxiliary subunits Neto1 and Neto2 regulate the GluK1 receptor targeting to excitatory silent synapses through different molecular mechanisms and also modify receptor biophysics through distinct mechanisms.

An intracellular H9 motif facilitates the highly localised axonal surface expression of CB1R.

The co-chaperone CHORDC1 is specifically required for epidermal growth factor receptor trafficking and signaling in Caenorhabditis elegans and in human cells.

D-serine has a major role in the regulation of NMDA receptors not only contributing to its activation as the receptors co-agonist, but also by regulating specifically GluN2B-NMDA receptor trafficking and synaptic content at developing hippocampal synapses.

The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.

The subcellular localization of the prolyl hydroxylase oxygen sensor in C. elegans neurons is regulated by p38 MAP kinase signaling.

β-arrestins recruit Nedd4 ubiquitin E3 ligase to mGlu7 receptor and facilitate ubiquitination, endocytosis, ERK signaling, and stability of mGlu7 at presynaptic terminals.

The tetraspanin CD81 uses its ectodomain to export CD19, and the interaction of the two proteins is dynamically regulated by B cell activation state.

Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.

There are at least two separate pathways for AMPA receptor recycling, which are regulated by synaptic activity.