2,581 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Pharmacology: A Swiss army knife for targeting receptors

    Johansen B Amin, Lonnie P Wollmuth
    A compound can change the activity of NMDA receptors in some regions of a synapse without affecting those in other regions.
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    1. Cell Biology
    2. Developmental Biology

    Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

    Yuwei Jiang et al.
    The activation of beige adipocyte thermogenesis by cold temperatures and β3-adrenergic receptor agonists induce beige adipocyte formation, function and perdurance.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Chromosomes and Gene Expression

    Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

    Kevin Monahan et al.
    Biochemical and genetic experiments show that Ebf and Lhx2 cooperate to specify olfactory receptor enhancers, which cooperate to drive olfactory receptor expression.
    1. Neuroscience

    Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

    Paula A Pousinha et al.
    The APP intracellular domain (AICD) physiologically regulates synaptic GluN2B-containing NMDA receptor current, a process that could contribute to pathological Alzheimer's disease-related synaptic failure upon increase of AICD levels in adult neurons.
    1. Neuroscience

    Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

    Shigetomo Suyama et al.
    Neurons in the hypothalamus that promote satiety manifest plasticity of their response to the excitatory transmitter, glutamate, by re-organizing the composition of a specific glutamare receptor.
    1. Neuroscience

    Synaptic plasticity through activation of GluA3-containing AMPA-receptors

    Maria C Renner et al.
    A novel form of hippocampal synaptic plasticity is expressed by a change in channel function of GluA3-containing AMPA-receptors.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences

    Asaf Madi et al.
    A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.

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