2,858 results found
    1. Structural Biology and Molecular Biophysics

    Automated cryo-EM structure refinement using correlation-driven molecular dynamics

    Maxim Igaev et al.
    Correlation-driven molecular dynamics provides a fully automated and human-bias-free framework for quantitative interpretation of modern cryo-electron microscopy data.
    1. Cell Biology
    2. Genetics and Genomics

    Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome

    Martin Wegner et al.
    Cloning-free 3Cs technology is developed for the generation of sequence-bias-free covalently closed circular synthesized (3Cs) CRISPR/Cas gRNA libraries that can interrogate the coding and noncoding human genome.
    1. Microbiology and Infectious Disease

    Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

    Eva Istvan et al.
    The malaria parasite Niemann-Pick Type C1-related protein is an important new antimalarial target.
    1. Epidemiology and Global Health

    External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

    Malia SQ Murphy et al.
    Gestational age estimation models derived from newborn screening bloodspot samples are effective on data obtained from both heel prick and cord blood samples in low-resource settings.
    1. Microbiology and Infectious Disease

    Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

    Efraín E Rivera-Serrano et al.
    Quasi-enveloped hepatitis A virions undergo clathrin-mediated endocytosis, followed by ALIX-dependent trafficking to lysosomes where the quasi-envelope is degraded, triggering uncoating of the RNA genome in association with lysosomal membrane rupture.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

    Itamar Lev et al.
    In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Neuroscience

    Neurocalcin regulates nighttime sleep and arousal in Drosophila

    Ko-Fan Chen et al.
    The neuronal calcium sensor Neurocalcin regulates sleep and arousal thresholds during the night in Drosophila.
    1. Plant Biology

    Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism

    Isabel ML Saur et al.
    Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.

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