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    1. Developmental Biology
    2. Neuroscience

    Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2

    Verity Johnson et al.
    ROBO isoforms with minute sequence variations have significant and distinct functions in axon guidance.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Anaerobic Bacteria: Solving a shuttle mystery

    Bridget Conley, Jeffrey Gralnick
    Shewanella oneidensis bacteria use an abiotic reaction to help shuttle electrons outside of the cell.
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    1. Developmental Biology
    2. Neuroscience

    Lmx1b is required at multiple stages to build expansive serotonergic axon architectures

    Lauren J Donovan et al.
    A continuously expressed LIM HD factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of a long-range profusely arborized neuromodulatory axonal projection pathway.
    1. Cancer Biology
    2. Neuroscience

    Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

    Kelda Chia et al.
    P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

    Joana R Carvalho et al.
    Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.
    1. Stem Cells and Regenerative Medicine

    Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

    Kefei Nina Li et al.
    Hair follicle epithelium and skin vasculature remodeling are coordinated during quiescence, and their cross-talking is associated with the timing of stem cell activation.
    1. Cell Biology
    2. Human Biology and Medicine

    Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

    Arpit Sharma et al.
    Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

    Rachel A Gottschalk et al.
    Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.
    1. Neuroscience

    Tactile sensory channels over-ruled by frequency decoding system that utilizes spike pattern regardless of receptor type

    Ingvars Birznieks et al.
    Perception of vibrotactile frequency depends on the neural discharge pattern rather than the afferent type, thus requiring a reevaluation of the notion of Pacinian/non-Pacinian channels in tactile sensory system.
    1. Neuroscience

    Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner

    Towako Hiraki-Kajiyama et al.
    In the brain of medaka fish, neuropeptide B acts directly downstream of estrogen in a female-specific but reversible manner to mediate female receptivity to male courtship.